Frequently Asked Questions About Gynazole-1®
 
  How effective is Gynazole·1 against Candida?
  What is bioadhesion?
  How is Gynazole·1 dosed?
  How fast does Gynazole·1 relieve symptoms?
  Should Gynazole·1 be taken at night to prevent leakage?
  Which Candida species is Gynazole·1 indicated for?
  What drug interactions are associated with Gynazole·1?
  Is there a risk of resistance to Gynazole·1?
 
Q: How effective is Gynazole·1 against Candida?
A. In a clinical study, 94% of patients with vaginal yeast infections were clinically cured 8–10 days post-treatment.* (1)
Q: What is bioadhesion?
A. Bioadhesion is the mechanism that enables Gynazole·1 to adhere to wet living tissue for days and to deliver a targeted, continuous release of medication. Bioadhesion is why Gynazole·1 is effective in treating a vaginal yeast infection in a single dose that can be taken at any time. Read more about how Gynazole·1 works.
Q: How is Gynazole·1 dosed?
A. Gynazole·1 offers the convenience of a single-dose yeast infection treatment. The recommended dose of Gynazole·1 is one applicatorful of cream (approximately 5 grams of the cream) intravaginally. This amount of cream contains approximately 100 mg of butoconazole nitrate.
Q: How fast does Gynazole·1 relieve symptoms?
A. In a clinical study, Gynazole·1 demonstrated a 74% decline in the incidence of severe symptoms, such as vaginal itching, within 24 hours.2 Click here to learn more about the quick symptom relief offered by Gynazole·1.
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Q: Should Gynazole·1 be taken at night to prevent leakage?
A.  Thanks to Site Release® bioadhesion technology, Gynazole·1 may be administered at any time of the day and followed immediately by normal activity. Click here to learn more about bioadhesion.
Q: Which Candida species is Gynazole·1 indicated for?
A. Gynazole·1 is indicated for vulvovaginal candidiasis (VVC) caused by all Candida species. On the other hand, Diflucan® and miconazole (the active ingredient in Monistat®) may not be as effective against some common Candida pathogens. (12,15) Click here to learn more about the efficacy of Gynazole·1.
Q: What drug interactions are associated with Gynazole·1?
A. There are no known drug interactions with Gynazole·1. Click here to learn more about the safety of Gynazole·1.
Q: Is there a risk of resistance to Gynazole·1?
A. Unlike Diflucan, which has a risk of resistance with repeated use, the emergence of resistance to butoconazole, the active ingredient in Gynazole·1, has not been seen. (23)
Footnote References
*Therapeutic efficacy is based on clinical cure rate (relief of yeast infection symptoms) and microbiologic cure (pathogen eradication). The therapeutic efficacy rate after 30 days for the one-dose treatment (Gynazole·1) was 62% as compared to 68% for the 7-day treatment (miconazole-7). The clinical cure rate for miconazole-7 at 8–10 days was 96%. Based on these results, there is no statistically significant difference between these yeast infection treatments. (1,2)

Diflucan® is a registered trademark of the Pfizer Corporation
Monistat® is a registered trademark of McNeil-PPC.
 
Important Gynazole1 Information
  Please see full Prescribing Information
  Safety Information Footnote References
 
 
 
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